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Research

Effect of Pantoprazole on the Symptoms of Acid Reflux Disease in Adult Patients (BY1023/M3-341)

12 Oct 2007
The aim of the present study is to identify factors (such as symptom patterns and symptom scores) that influence the response to treatment with pantoprazole using different evaluation methods (e.g. ... › More

The Prevalence and Significance of Gastro-Oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation

14 Aug 2007
This study will determine the prevalence, severity and significance of symptomatic and silent GOR in adults with CF before and after lung transplant using 24hr oesophageal pH monitoring, a valid ... › More

A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated Diarrhea

9 Aug 2007
This study aims to determine if an investigational drug is safe and effective for treating symptoms of C. difficile-associated diarrhea (CDAD) and lowering the risk of repeat episodes of CDAD. The ... › More

Intravenous Mepolizumab In Children With Eosinophilic Esophagitis

31 Jul 2007
This study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of intravenous mepolizumab in pediatric subjects with eosinophilic esophagitis. › More

A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum

19 Jul 2007
This is a multi-centre randomised trial comparing long course (LC) preoperative chemoradiation with short course (SC) preoperative radiotherapy for patients with localised T3 rectal cancer. › More

ASTERIX: Low Dose ASA and Nexium

2 Jun 2007
The purpose of the study is to evaluate the effect of esomeprazole 20 mg od versus placebo for the prevention of gastric and/or duodenal ulcers in patients taking low-dose ASA. › More

A Study To Investigate GW427353 In Subjects With Irritable Bowel Syndrome (IBS)

15 May 2007
This study will test the hypothesis that GW427353, a beta-3 adrenergic agonist, will relieve IBS pain or discomfort and associated symptoms in IBS patients. › More

Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps

4 May 2007
This randomized phase III trial is studying celecoxib to see how well it works compared to a placebo in preventing the development of adenomatous colorectal polyps in patients who have had at least ... › More

An Open Single Centre Study To Assess Treatment of Chronic Constipation in Children

23 Apr 2007
The purpose of this study was to evaluate the safety and efficacy of Movicol in the treatment of chronic constipation in children. › More

A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer

7 Mar 2007
This study will compare the efficacy and safety of intermittent oral Xeloda plus Eloxatin with that of fluorouracil/leucovorin in patients who have had surgery for colon cancer and no previous ... › More

Trials

The Rabeprazole and Esomeprazole Reflux Assessment Trial (TREAT)

8 Oct 2007
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or ... › More

A Study of Abatacept in Patients With Active Crohn's Disease

13 Aug 2007
The purpose of this clinical research study is to learn if abatacept can improve signs and symptoms of active Crohn's Disease in patients who have not had an adequate response to other therapies. The ... › More

A Single Arm Trial of Oxaliplatin and 5FU With Concurrent Radiation in Patients With Metastatic Rectal Cancer

1 Aug 2007
This trial is a single-arm study for patients presenting with both local and metastatic adenocarcinoma of rectum. The aims of the trial are (1) to determine the tolerability rate, and (2) to ... › More

A Study of Visilizumab in Subjects With Intravenous Steroid-Refractory Ulcerative Colitis

24 Jul 2007
The purpose of this study is to compare the efficacy of visilizumab to placebo in subjects with intravenous steroid-refractory ulcerative colitis. › More

Cirrhotic Ascites Treatment With Satavaptan in Patients With Ascites Due to Cirrhosis of the Liver (CATS)

7 Jul 2007
To evaluate the efficacy of satavaptan on top of conventional treatment in the treatment of clinically evident ascites in patients with cirrhosis of the liver and to evaluate the tolerability and ... › More

A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn's Disease

3 Jul 2007
The purpose of this study is to determine whether CCX282-B is effective in treating patients with moderate to severe Crohn's Disease. › More

Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on LDA (Oberon)

22 Jun 2007
The purpose of this study is to compare the effect of esomeprazole 20 and 40 mg once daily versus placebo on the occurrence of peptic ulcers during 26 weeks in subjects on continuous low-dose ... › More

PRIME: Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy

2 Jun 2007
The purpose of this study is to determine the treatment effect of panitumumab in combination with FOLFOX compared to FOLFOX alone as first line therapy for metatstatic colorectal cancer › More

Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection

17 May 2007
The purpose of this clinical research study is to learn if the study drug entecavir will prevent the recurrence of hepatitis B virus in subjects who receive an orthotopic liver transplant (OLT). › More

Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-Abdominal Infection (cIAI)

2 May 2007
This is a study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI. Subjects will be followed for efficacy through the test-of-cure ... › More

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